Nigericin
Product Specifications
CAS Number
28380-24-7
Target
Sodium Channel, Apoptosis, NOD-like Receptor (NLR), Caspase, Pyroptosis, Potassium Channel, Antibiotic, Wnt/beta-catenin, Antibacterial
Related Pathways
Apoptosis, Stem Cells, Proteases/Proteasome, Cytoskeletal Signaling, Microbiology/Virology, Membrane transporter/Ion channel, Immunology/Inflammation
Purity
0.985
Bioactivity
Nigericin is a polyether antibiotic with potent antimicrobial, antimalarial, anticoronaviral and anticancer activities. It is capable of promoting cellular potassium efflux, inducing Caspase-1/GSDMD and Caspase-3-mediated cellular pyroptosis and apoptosis in triple-negative breast cancer, and inducing apoptosis in PEL (primary exudative lymphoma) cells through mitochondrial dysfunction and Wnt/β-catenin signaling downregulation.
Smiles
C[C@H]1[C@]2(O[C@@](C)(C1)[C@@]3(O[C@@](C)(CC3)[C@@]4(O[C@](C[C@@H]4C)([C@]5(O[C@](CO)(O)[C@H](C)C[C@@H]5C)[H])[H])[H])[H])O[C@H](C[C@@H]6O[C@@]([C@H](C(O)=O)C)([C@@H](C)CC6)[H])C[C@@H](OC)[C@H]2C
Molecular Formula
C40H68O11
Molecular Weight
724.96
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
orb2575081 100 µg
Transcription factor E2F3 E2F3 Rabbit Polyclonal Antibody (Biotin)
Sign In for Pricing
View Details 
