NF157

NF157 significantly decreases the expression of metalloproteinase (MMP) -3, MMP-13, which can be used in the treatment of osteoarthritis (OA) . NF157 is a highly selective nanomolar P2Y11 antagonist (pKi: 7.35) . The IC50s are 463 nM, 1811 μM, 170 μM for P2Y11 (Ki=44.3 nM), P2Y1 (Ki=187 μM), P2Y2 (Ki=28.9 μM), respectively.

[Na].[Na].[Na].[Na].[Na].[Na].OS(=O)(=O)c1cc(c2c(NC(=O)c3ccc(F)c(NC(=O)c4cccc(NC(=O)Nc5cccc(c5)C(=O)Nc5cc(ccc5F)C(=O)Nc5ccc(c6cc(cc(c56)S(O)(=O)=O)S(O)(=O)=O)S(O)(=O)=O)c4)c3)ccc(c2c1)S(O)(=O)=O)S(O)(=O)=O