NF157
Product Specifications
CAS Number
104869-26-3
Target
P2Y Receptor|||COX
Related Pathways
GPCR/G Protein|||Immunology/Inflammation|||Neuroscience
Bioactivity
NF157 significantly decreases the expression of metalloproteinase (MMP) -3, MMP-13, which can be used in the treatment of osteoarthritis (OA) . NF157 is a highly selective nanomolar P2Y11 antagonist (pKi: 7.35) . The IC50s are 463 nM, 1811 ?M, 170 ?M for P2Y11 (Ki=44.3 nM), P2Y1 (Ki=187 ?M), P2Y2 (Ki=28.9 ?M), respectively.
Smiles
[Na].[Na].[Na].[Na].[Na].[Na].OS(=O)(=O)c1cc(c2c(NC(=O)c3ccc(F)c(NC(=O)c4cccc(NC(=O)Nc5cccc(c5)C(=O)Nc5cc(ccc5F)C(=O)Nc5ccc(c6cc(cc(c56)S(O)(=O)=O)S(O)(=O)=O)S(O)(=O)=O)c4)c3)ccc(c2c1)S(O)(=O)=O)S(O)(=O)=O
Molecular Formula
C49H28F2N6Na6O23S6
Molecular Weight
1437.1
Shipping Conditions
Cool pack
Storage Temperature
-20°C
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