NCT-502
Product Specifications
CAS Number
1542213-00-2
Target
Dehydrogenase
Related Pathways
Metabolism
Purity
0.996
Bioactivity
NCT-502 (N- (4,6-dimethylpyridin-2-yl) -4-[5- (trifluoromethyl) pyridin-2-yl]piperazine-1-carbothioamide) is a human phosphoglycerate dehydrogenase inhibitor, cytotoxic to PHGDH-dependent cancer cells. It decreases glucose-derived serine production and it has an IC50 of 3.7 μM against PHGDH.
Smiles
Cc1cc(C)nc(NC(=S)N2CCN(CC2)c2ccc(cn2)C(F)(F)F)c1
Molecular Formula
C18H20F3N5S
Molecular Weight
395.45
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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