MS4078

2229036-62-6

PROTACs, ALK

Angiogenesis, Tyrosine Kinase/Adaptors, PROTAC

0.9874

MS4078 is an inhibitor and aplastic lymphoma kinase (ALK) PROTAC (degrader) based on Cereblon ligand, with a Kd of 19 nM for binding affinity to ALK.

O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2NCCNC(CN4CCC(CC4)C5=CC(OC(C)C)=C(NC=6N=C(NC7=C(S(C(C)C)(=O)=O)C=CC=C7)C(Cl)=CN6)C=C5C)=O

C45H52ClN9O8S

914.47

Ice Packs

-20°C