MRT199665
Product Specifications
CAS Number
1456858-57-3
Target
Others, Apoptosis, AMPK, SIK
Related Pathways
Chromatin/Epigenetic, Apoptosis, PI3K/Akt/mTOR signaling, Others
Bioactivity
MRT199665 is an effective and ATP-competitive, selective MARK/SIK/AMPK inhibitor (IC50s of 2/2/3/2 nM, 10/10 nM, and 110/12/43 nM for MARK1/MARK2/MARK3/MARK14, AMPKα1/AMPKα2, and SIK1/SIK2/SIK3, respectively) . MRT199665 suppresses the phosphorylation of SIK substrate CRTC3 at S370. MRT199665 induces apoptosis in MEF2C-activated human acute myeloid leukemia (AML) cells.
Smiles
CC1(C)C(=O)N([C@H]2CCc3c2cccc3O)c2nc(Nc3cccc(CN4CCCC4)c3)ncc12
Molecular Formula
C28H31N5O2
Molecular Weight
469.58
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
GTR15174913 1 Vial
Lentiviral mouse Spata5l1 shRNA (UAS) - Lentiviral mouse Spata5l1 shRNA (UAS, RFP) plasmid
Sign In for Pricing
View Details 
MBS2507347-01 24 Tests (Limit 1)
Mouse RasGAP (Ras GTPase Activating Protein) ELISA Kit
Sign In for Pricing
View Details MBS2507347-02 48 Tests
Mouse RasGAP (Ras GTPase Activating Protein) ELISA Kit
Sign In for Pricing
View Details MBS2507347-03 96 Tests
Mouse RasGAP (Ras GTPase Activating Protein) ELISA Kit
Sign In for Pricing
View Details MBS2507347-04 5x 96 Tests
Mouse RasGAP (Ras GTPase Activating Protein) ELISA Kit
Sign In for Pricing
View Details MBS2507347-05 10x 96 Tests
Mouse RasGAP (Ras GTPase Activating Protein) ELISA Kit
Sign In for Pricing
View Details