MRT199665
Product Specifications
CAS Number
1456858-57-3
Target
Others, Apoptosis, AMPK, SIK
Related Pathways
Chromatin/Epigenetic, Apoptosis, PI3K/Akt/mTOR signaling, Others
Bioactivity
MRT199665 is an effective and ATP-competitive, selective MARK/SIK/AMPK inhibitor (IC50s of 2/2/3/2 nM, 10/10 nM, and 110/12/43 nM for MARK1/MARK2/MARK3/MARK14, AMPKα1/AMPKα2, and SIK1/SIK2/SIK3, respectively) . MRT199665 suppresses the phosphorylation of SIK substrate CRTC3 at S370. MRT199665 induces apoptosis in MEF2C-activated human acute myeloid leukemia (AML) cells.
Smiles
CC1(C)C(=O)N([C@H]2CCc3c2cccc3O)c2nc(Nc3cccc(CN4CCCC4)c3)ncc12
Molecular Formula
C28H31N5O2
Molecular Weight
469.58
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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