MMV390048
Product Specifications
CAS Number
1314883-11-8
Target
Parasite, PI4K
Related Pathways
PI3K/Akt/mTOR signaling, Microbiology/Virology
Purity
0.9828
Bioactivity
MMV390048 is an antimalarial agent and is a representative of a new chemical class of Plasmodium PI4K inhibitor (Kdapp=0.3 μM) . MMV390048 binds to the ATP binding site of Plasmodium PI4K and does not bind to other P. falciparum and human kinases apart from human PIP4K2C, thus alleviating potential kinase-mediated safety concerns.
Smiles
CS(=O)(=O)c1ccc(cc1)-c1cnc(N)c(c1)-c1ccc(nc1)C(F)(F)F
Molecular Formula
C18H14F3N3O2S
Molecular Weight
393.38
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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