Pevonedistat hydrochloride
Product Specifications
CAS Number
1160295-21-5
Target
NEDD8, Apoptosis
Related Pathways
Metabolism, Apoptosis
Purity
0.9931
Bioactivity
Pevonedistat hydrochloride (MLN4924 hydrochloride) is a selective and potent NEDD8 activating enzyme inhibitor (IC50: 4.7 nM) that induces apoptosis and cell cycle inhibition in cancer cells, and is used in the study of acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) . Pelubiprofen has been used in the study of AML and MDS.)
Smiles
N(C1=C2C(N(C=C2)[C@@H]3C[C@@H](COS(N)(=O)=O)[C@@H](O)C3)=NC=N1)[C@@H]4C=5C(CC4)=CC=CC5.Cl
Molecular Formula
C21H26ClN5O4S
Molecular Weight
479.98
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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