L-873724
Product Specifications
CAS Number
603139-12-4
Target
Others, Cysteine Protease
Related Pathways
Others, Proteases/Proteasome
Bioactivity
L-873724 inhibits bone resorption. L-873724 is an effective, selective, and reversible non-basic cathepsin K inhibitor (IC50s: 0.2, 178, 264, and 5239 nM for cathepsin K, cathepsin S, cathepsin L, cathepsin B, respectively) . L-873724 also shows an IC50 of 0.5 nM for rabbit cathepsin K.
Smiles
CC(C)C[C@H](N[C@@H](c1ccc(cc1)-c1ccc(cc1)S(C)(=O)=O)C(F)(F)F)C(=O)NCC#N
Molecular Formula
C23H26F3N3O3S
Molecular Weight
481.53
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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