CLZ-8
Product Specifications
CAS Number
678158-55-9
Target
Apoptosis|||Bcl-2 Family
Related Pathways
Apoptosis
Purity
0.9985
Bioactivity
CLZ-8 (Mcl1-IN-8) is an orally active inhibitor of Mcl-1-PUMA (p53 up-regulated mediator of apoptosis) with radioprotective properties.CLZ-8 ameliorates radiation-induced HUVEC cell damage and reduces apoptosis counts, and inhibits radiation-induced overexpression of PUMA.
Smiles
OCCN1CCN(CC1)C1=NC(=O)\C(S1)=C\c1ccc(cc1)-c1ccccc1
Molecular Formula
C22H23N3O2S
Molecular Weight
393.5
Shipping Conditions
Cool pack
Storage Temperature
-20°C
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