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CLZ-8

Product Specifications

CAS Number

678158-55-9

Target

Apoptosis|||Bcl-2 Family

Related Pathways

Apoptosis

Purity

0.9985

Bioactivity

CLZ-8 (Mcl1-IN-8) is an orally active inhibitor of Mcl-1-PUMA (p53 up-regulated mediator of apoptosis) with radioprotective properties.CLZ-8 ameliorates radiation-induced HUVEC cell damage and reduces apoptosis counts, and inhibits radiation-induced overexpression of PUMA.

Smiles

OCCN1CCN(CC1)C1=NC(=O)\C(S1)=C\c1ccc(cc1)-c1ccccc1

Molecular Formula

C22H23N3O2S

Molecular Weight

393.5

Shipping Conditions

Cool pack

Storage Temperature

-20°C

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