Gelsevirine

Gelsevirine is the major alkaloid in Gelsemium elegans with potent anxiolytic effects. The anxiolytic mechanism of Gelsevirine may be involved in the agonist action of the glycine receptor in the brain. Gelsevirine has anti-proliferation activity with IC50 values of 1.41 mM and 1.22 mM for SW480 cells and MGC80-3 cells, respectively[1][2][3].

Product Specifications

CAS Number

[38990-03-3]

UNSPSC

12352005

Target

Others

Type

Natural Products

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/gelsevirine.html

Purity

99.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1[C@]([C@H](OC2)C[C@@H]3[C@@]2([H])[C@@]4([H])N5C)(C6=CC=CC=C6N1OC)[C@]4([H])[C@]3(C5)C=C

Molecular Formula

C21H24N2O3

Molecular Weight

352.43

References & Citations

[1]Hua-Hai Zhang, et al. Characterization of Gelsevirine Metabolites in Rat Liver S9 by Accurate Mass Measurements Using High-Performance Liquid chromatography/quadrupole-time-of-flight Mass Spectrometry. Rapid Commun Mass Spectrom. 2019 Jul 30;33 (14) :1179-1184.|[2]Ming Liu, et al. The Active Alkaloids of Gelsemium Elegans Benth. Are Potent Anxiolytics. Psychopharmacology (Berl) . 2013 Feb;225 (4) :839-51.|[3]HUANG Jing, et al. Cytotoxic effects of alkaloidal compounds from Gelsemium elegans Benth on the tumor cells of digestive system in vitro. Strait Pharmaceutical Journal, 2010 , 22 (3) :197-200.