M-525
Product Specifications
CAS Number
2173582-08-4
Target
Epigenetic Reader Domain, Others
Related Pathways
Chromatin/Epigenetic, Others
Bioactivity
M-525 binds to menin (IC50: 3 nM) and achieves low nanomolar potencies in cell growth inhibition and in the suppression of MLL regulated gene expression in MLL leukemia cells. M-525 is a first-in-class, highly potent, irreversible, and covalent menin-MLL protein-protein interaction inhibitor. It has an Anti-leukemia activity.
Smiles
[C@@](C#N)([C@@]1([C@@H](NC(OC)=O)CCC1)[H])(C2=CC(F)=CC=C2)[C@H]3CCN(CC4CN(C4)C5=CC=C(S(=O)(=O)C6CN(C(/C=C/CN(C)C)=O)C6)C=C5)CC3
Molecular Formula
C39H51FN6O5S
Molecular Weight
734.92
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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