LY 345899
Product Specifications
CAS Number
10538-99-5
Target
DHFR, Dehydrogenase
Related Pathways
Metabolism, Cell Cycle/Checkpoint, DNA Damage/DNA Repair
Purity
0.997
Bioactivity
LY 345899 is a folate analog that inhibits methylenetetrahydrofolate dehydrogenase and MTHFD2, with IC50 values of 96 nM and 663 nM, respectively, and a Ki of 18 nM for MTHFD1.
Smiles
Nc1nc2NCC3CN(C(=O)N3c2c(=O)[nH]1)c1ccc(cc1)C(=O)N[C@@H](CCC(O)=O)C(O)=O
Molecular Formula
C20H21N7O7
Molecular Weight
471.42
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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