Lofepramine
Product Specifications
CAS Number
23047-25-8
Target
Others, Adrenergic Receptor, 5-HT Receptor, Norepinephrine
Related Pathways
GPCR/G Protein, Neuroscience, Others
Purity
0.9838
Bioactivity
Lofepramine (Leo 640) is a potent tricyclic antidepressant that is extensively metabolized to desipramine. It inhibits the serotonin and norepinephrine transporters by inhibiting neurons with Kd values of 70 and 5.4 nM, respectively, with weak antagonism of serotonin, histamine and muscarinic receptors.
Smiles
C(CCN(CC(=O)C1=CC=C(Cl)C=C1)C)N2C=3C(CCC=4C2=CC=CC4)=CC=CC3
Molecular Formula
C26H27ClN2O
Molecular Weight
418.96
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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