Lestaurtinib
Product Specifications
CAS Number
111358-88-4
Target
Trk receptor|||FLT|||Apoptosis|||JAK|||STAT
Related Pathways
Angiogenesis|||JAK/STAT signaling|||Tyrosine Kinase/Adaptors|||Apoptosis|||Stem Cells|||Chromatin/Epigenetic
Purity
0.9917
Bioactivity
Lestaurtinib (CEP 701) is an orally available and selective inhibitor of FMS-like tyrosine kinase-3 (FLT3, IC50: 0.9 nM), which inhibits FLT3 autophosphorylation in vitro.Lestaurtinib promotes the expression of c-MYC, inhibits the phosphorylation of RPTKs, and has high affinity for TrkA and JAK2. Lestaurtinib promotes c-MYC expression, inhibits phosphorylation of RPTKs, has a high affinity for TrkA and JAK2, induces apoptosis and cell growth arrest, and can be used to study leukemia.
Smiles
C[C@]12N3C=4C=5N(C=6C(C5C7=C(C4C=8C3=CC=CC8)CNC7=O)=CC=CC6)[C@](O1)(C[C@@]2(CO)O)[H]
Molecular Formula
C26H21N3O4
Molecular Weight
439.46
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
