Leptomycin B
Product Specifications
CAS Number
87081-35-4
Target
Antifungal, CRM1, Antibiotic
Related Pathways
Membrane transporter/Ion channel, Microbiology/Virology
Purity
0.9971
Bioactivity
Leptomycin B (LMB) is a potent inhibitor of the nuclear export of proteins and is a potent antifungal antibiotic blocking the eukaryotic cell cycle. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue.
Smiles
CC\C(\C=C\[C@H]1OC(=O)C=C[C@@H]1C)=C\[C@H](C)C\C=C\C(\C)=C\[C@@H](C)C(=O)[C@@H](C)[C@H](O)[C@@H](C)C\C(C)=C\C(O)=O
Molecular Formula
C33H48O6
Molecular Weight
540.73
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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