Lactacystin
Product Specifications
CAS Number
133343-34-7
Target
Protease, Apoptosis, cAMP
Related Pathways
GPCR/G Protein, Proteases/Proteasome, Apoptosis
Bioactivity
Lactacystin is an orally active, irreversible, and cell-permeable proteasome inhibitor (IC50 = 4.8 μM) that also inhibits the lysosomal enzyme cathepsin A. It induces apoptosis and cell cycle arrest, possesses anticancer, antiviral, and antioxidant activities, can penetrate the blood-brain barrier, and is commonly used in the construction of Parkinson’s disease and dementia models.
Smiles
C(SC[C@H](NC(C)=O)C(O)=O)(=O)[C@@]1([C@H](C(C)C)O)[C@@H](O)[C@@H](C)C(=O)N1
Molecular Formula
C15H24N2O7S
Molecular Weight
376.43
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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