Lactacystin
Product Specifications
CAS Number
133343-34-7
Target
Protease, Apoptosis, cAMP
Related Pathways
GPCR/G Protein, Proteases/Proteasome, Apoptosis
Bioactivity
Lactacystin is an orally active, irreversible, and cell-permeable proteasome inhibitor (IC50 = 4.8 μM) that also inhibits the lysosomal enzyme cathepsin A. It induces apoptosis and cell cycle arrest, possesses anticancer, antiviral, and antioxidant activities, can penetrate the blood-brain barrier, and is commonly used in the construction of Parkinson’s disease and dementia models.
Smiles
C(SC[C@H](NC(C)=O)C(O)=O)(=O)[C@@]1([C@H](C(C)C)O)[C@@H](O)[C@@H](C)C(=O)N1
Molecular Formula
C15H24N2O7S
Molecular Weight
376.43
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
bsm-60643R-BF680 100 µL
Lysozyme Recombinant Antibody, AbBy Fluor™ 680 Conjugated
Sign In for Pricing
View Details 
MBS6410538-01 0.1 mL
CD99 (CD99, HBA71, MIC2, MIC2X, MIC2Y, MSK5X, CD99 antigen, 12E7, E2 antigen, Protein MIC2, T-cell surface glycoProtein E2) (FITC)
Sign In for Pricing
View Details MBS6410538-02 5x 0.1 mL
CD99 (CD99, HBA71, MIC2, MIC2X, MIC2Y, MSK5X, CD99 antigen, 12E7, E2 antigen, Protein MIC2, T-cell surface glycoProtein E2) (FITC)
Sign In for Pricing
View Details 
ARP68242_P050-FITC 100 µL
CWF19L2 Antibody - N-terminal region : FITC (ARP68242_P050-FITC)
Sign In for Pricing
View Details 
KN405390 1 Kit
GABA A Receptor alpha 1 (GABRA1) Human Gene Knockout Kit (CRISPR)
Sign In for Pricing
View Details MBS1329548-01 0.02 mg (E-Coli)
Recombinant Rabbit Keratin, type I cytoskeletal 12 (KRT12)
Sign In for Pricing
View Details