KT5823
Product Specifications
CAS Number
126643-37-6
Target
Antibiotic|||Antibacterial|||Apoptosis|||PKA|||PKC
Related Pathways
Tyrosine Kinase/Adaptors|||Apoptosis|||Chromatin/Epigenetic|||Microbiology/Virology|||Cytoskeletal Signaling
Purity
0.95
Bioactivity
KT5823 is a selective and potent cGMP-dependent protein kinase (PKG) inhibitor with inhibitory effects on PKA and PKC.KT5823 increases thyroid-stimulating hormone-induced (Na+/I- symporter) NIS expression and iodide ion uptake by modulating sodium iodide symporter protein expression and activity in thyroid cells. KT5823 induces apoptosis.
Smiles
C[C@]12N3C=4C5=C(C6=C(C4C=7C3=CC=CC7)CN(C)C6=O)C=8C(N5[C@](O1)(C[C@@]2(C(OC)=O)OC)[H])=CC=CC8
Molecular Formula
C29H25N3O5
Molecular Weight
495.53
Shipping Conditions
Cool pack
Storage Temperature
-20°C
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