K777
Product Specifications
CAS Number
233277-99-1
Target
SARS-CoV, CCR, Cysteine Protease, Parasite, Cytochromes P450, Virus Protease
Related Pathways
Proteases/Proteasome, Microbiology/Virology, Metabolism, GPCR/G Protein, Immunology/Inflammation
Purity
0.9971
Bioactivity
K777 is a potent, orally active, and irreversible inhibitor of cysteine protease, functioning as a potent CYP3A4 inhibitor (IC50 = 60 nM) and a selective CCR4 antagonist, which inhibits chemotaxis. K777 irreversibly inhibits Cruzain, the major cysteine protease of Trypanosoma cruzi, and cathepsins B and L, targeting cathepsin-mediated cell entry and exhibiting broad-spectrum antiviral activity. It inhibits EBOV and SARS-CoV pseudovirus entry with IC50 values of 0.87 nM and 0.68 nM, respectively.
Smiles
CN1CCN(CC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCc1ccccc1)\C=C\S(=O)(=O)c1ccccc1
Molecular Formula
C32H38N4O4S
Molecular Weight
574.73
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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