Rebamipide
Product Specifications
CAS Number
90098-04-7
Target
Prostaglandin Receptor, Free radical scavengers, COX
Related Pathways
Immunology/Inflammation, Oxidation-Reduction, GPCR/G Protein, Neuroscience
Purity
0.999
Bioactivity
Rebamipide (OPC12759) is a quinolinone derivative with anti-ulcer and anti-inflammatory activities. Rebamipide induces cyclooxygenase 2 (COX2) synthesis which results in an increase in endogenous prostaglandin synthesis in the gastric mucosa. This agent also inhibits H. pylori-induced production of tumor necrosis factor (TNF) alpha and subsequent inflammation of the gastric mucosa. In addition, rebamipide scavenges oxygen-derived free radicals that potentially cause mucosal injury, and stimulates prostaglandin EP4 receptor gene expression followed by mucous secretion, thereby enhancing the gastric mucosal defense.
Smiles
OC(=O)C(CC1=CC(=O)NC2=C1C=CC=C2)NC(=O)C1=CC=C(Cl)C=C1
Molecular Formula
C19H15ClN2O4
Molecular Weight
370.79
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
