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JNJ-10198409

Product Specifications

CAS Number

627518-40-5

Target

PDGFR

Related Pathways

Angiogenesis, Tyrosine Kinase/Adaptors

Purity

0.9851

Bioactivity

JNJ- 10198409 is a relatively selective and ATP competitive PDGF-RTK inhibitor (IC50=2 nM) . JNJ-10198409 has good activity against PDGFR-β kinase (IC50=4.2 nM) and PDGFR-α kinase (IC50=45 nM) . It is a dual-mechanism, antiangiogenic, and tumor cell antiproliferative agent.

Smiles

COc1cc2Cc3c(Nc4cccc(F)c4)n[nH]c3-c2cc1OC

Molecular Formula

C18H16FN3O2

Molecular Weight

325.34

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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