JNJ-10198409
Product Specifications
CAS Number
627518-40-5
Target
PDGFR
Related Pathways
Angiogenesis, Tyrosine Kinase/Adaptors
Purity
0.9851
Bioactivity
JNJ- 10198409 is a relatively selective and ATP competitive PDGF-RTK inhibitor (IC50=2 nM) . JNJ-10198409 has good activity against PDGFR-β kinase (IC50=4.2 nM) and PDGFR-α kinase (IC50=45 nM) . It is a dual-mechanism, antiangiogenic, and tumor cell antiproliferative agent.
Smiles
COc1cc2Cc3c(Nc4cccc(F)c4)n[nH]c3-c2cc1OC
Molecular Formula
C18H16FN3O2
Molecular Weight
325.34
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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