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JND3229

Product Specifications

CAS Number

2260886-64-2

Target

EGFR

Related Pathways

Tyrosine Kinase/Adaptors|||Angiogenesis|||JAK/STAT signaling

Purity

0.9875

Bioactivity

JND3229 is a reversible EGFRC797S inhibitor with IC50 values of 5.8, 6.8 and 30.5 nM for EGFRL858R/T790M/C797S, EGFRWT and EGFRL858R/T790M, respectively. JND3229 has good anti-proliferative activity and can effectively inhibit tumour growth in vivo. JND3229 can be used in cancer research, especially in non-small cell carcinoma.

Smiles

CCC(=O)N[C@H]1CC[C@@H](CC1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(C)c3)nc12)c1ccccc1Cl

Molecular Formula

C33H41ClN8O2

Molecular Weight

617.18

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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