JH-VIII-157-02
Product Specifications
CAS Number
1639422-97-1
Target
ALK, Microtubule Associated
Related Pathways
Cytoskeletal Signaling, Tyrosine Kinase/Adaptors, Angiogenesis
Purity
0.9958
Bioactivity
JH-VIII-157-02 is an inhibitor of ALK and inhibits echinoderm microtubule-associated protein-like 4-ALK (EML4-ALK) with IC50s of 2 nM for EML4-ALK G1202R, EML4-ALKwt, EML4-ALK C1156Y, EML4-ALK F1174L, and EML4-ALK F1174L.
Smiles
CCc1cc2C(=O)c3c([nH]c4cc(ccc34)C#N)C(C)(C)c2cc1-c1cnn(CC(=O)N(C)C)c1
Molecular Formula
C28H27N5O2
Molecular Weight
465.55
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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