JAK1-IN-4
Product Specifications
CAS Number
2091134-35-7
Target
JAK
Related Pathways
Stem Cells, Chromatin/Epigenetic, Tyrosine Kinase/Adaptors, JAK/STAT signaling, Angiogenesis
Bioactivity
JAK1-IN-4 is a selective JAK1 inhibitor (IC50s: 85 nM, 12.8 μM and >30 μM for JAK1, JAK2, and JAK3, respectively) . JAK1-IN-4 inhibits STAT3 phosphorylation in NCI-H 1975 cells (IC50, 227 nM) .
Smiles
N(C([C@@H](C)N1C[C@@H](C)N(C)CC1)=O)C2=C3C(C(=CN3)C4=NC(NC=5C(OC)=NN(C)C5)=NC=C4F)=CC=C2
Molecular Formula
C26H32FN9O2
Molecular Weight
521.59
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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