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Indibulin

Product Specifications

CAS Number

204205-90-3

Target

Microtubule Associated, Apoptosis, Chk

Related Pathways

Apoptosis, Cell Cycle/Checkpoint, Cytoskeletal Signaling

Purity

0.9983

Bioactivity

Indibulin (D 24851) is a synthetic small molecule with antimitotic and potential antineoplastic activities.Indibulin an orally applicable inhibitor of tubulin assembly, shows potent anticancer activity with a minimal neurotoxicity. Indibulin reduces inter-kinetochoric tension, produces aberrant spindles, activates mitotic checkpoint proteins Mad2 and BubR1, and induces mitotic arrest and apoptosis.

Smiles

Clc1ccc(Cn2cc(C(=O)C(=O)Nc3ccncc3)c3ccccc23)cc1

Molecular Formula

C22H16ClN3O2

Molecular Weight

389.83

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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