GSK2798745

Product Specifications

CAS Number

1419609-94-1

Target

TRP/TRPV Channel

Related Pathways

Membrane transporter/Ion channel

Bioactivity

GSK2798745 is an orally active transient receptor potential vanilloid 4 (TRPV4) ion channel blocker (IC50s: 1.8 and 1.6 nM for hTRPV4 and rTRPV4) . It is used in research for the treatment of pulmonary edema associated with congestive heart failure.

Smiles

CC(C)(O)c1cnc(cn1)N1C[C@@]2(CCC[C@](C)(Cn3cnc4ccc(cc34)C#N)C2)OC1=O

Molecular Formula

C25H28N6O3

Molecular Weight

460.53

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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