GNE-5729
Product Specifications
CAS Number
2026635-66-3
Target
IGluR, NMDAR
Related Pathways
Membrane transporter/Ion channel, Neuroscience
Purity
0.9985
Bioactivity
GNE-5729 is a positive allosteric modulator of NMDAR with the advantage of crossing the blood-brain barrier and being orally available, with EC50 values of 37 nM, 4.7 μM and 9.5 μM for GluN2A, GluN2C and GluN2D, respectively, and can be used for the study of neurological and psychiatric disorders.
Smiles
ClC1=C(N2C(=NC(CN3N=C(C(F)(F)F)C=C3Cl)=CC2=O)C=C1)[C@H]4[C@H](C#N)C4
Molecular Formula
C17H10Cl2F3N5O
Molecular Weight
428.2
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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