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GNE-5729

Product Specifications

CAS Number

2026635-66-3

Target

IGluR, NMDAR

Related Pathways

Membrane transporter/Ion channel, Neuroscience

Purity

0.9985

Bioactivity

GNE-5729 is a positive allosteric modulator of NMDAR with the advantage of crossing the blood-brain barrier and being orally available, with EC50 values of 37 nM, 4.7 μM and 9.5 μM for GluN2A, GluN2C and GluN2D, respectively, and can be used for the study of neurological and psychiatric disorders.

Smiles

ClC1=C(N2C(=NC(CN3N=C(C(F)(F)F)C=C3Cl)=CC2=O)C=C1)[C@H]4[C@H](C#N)C4

Molecular Formula

C17H10Cl2F3N5O

Molecular Weight

428.2

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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