GNE-0723
Product Specifications
CAS Number
1883518-31-7
Target
IGluR, NMDAR
Related Pathways
Neuroscience, Membrane transporter/Ion channel
Purity
0.9991
Bioactivity
GNE-0723 is a selective positive allosteric modulator of the NMDA receptor, with an EC50 of 21 nM for GluN2A. It can cross the blood-brain barrier (BBB) and improve outcomes in Dravet syndrome (DS) and Alzheimer's disease (AD) .
Smiles
C(F)(F)(F)C1=C(N2C(S1)=NC(CN3N=C(C(F)(F)F)C=C3Cl)=CC2=O)[C@H]4[C@H](C#N)C4
Molecular Formula
C16H8ClF6N5OS
Molecular Weight
467.78
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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