GNE-207
Product Specifications
CAS Number
2158266-58-9
Target
Histone Acetyltransferase, Epigenetic Reader Domain
Related Pathways
Chromatin/Epigenetic
Bioactivity
GNE-207 is a selective and orally bioavailable inhibitor of the bromodomain of CBP (IC50: 1 nM) . It has a selective index of >2500-fold against BRD4 (1) . GNE-207 displays excellent CBP potency (EC50: 18 nM for MYC expression in MV-4-11 cells) .
Smiles
CNC(=O)c1ccc(cn1)-c1cc2cccc(-c3nn(C4CCOCC4)c4CCN(Cc34)C(C)=O)c2cn1
Molecular Formula
C29H30N6O3
Molecular Weight
510.59
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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