GNE-049
Product Specifications
CAS Number
1936421-41-8
Target
Epigenetic Reader Domain, Histone Acetyltransferase
Related Pathways
Chromatin/Epigenetic
Purity
0.9867
Bioactivity
GNE-049 is a highly selective and potent inhibitor designed to target the CREB-binding protein (CBP) with high affinity, exhibiting an IC50 of 1.1 nM for the suppression of BRET and BRD4 activity, which consequently blocks prostate cancer cell proliferation in both in vitro and in vivo models.
Smiles
O=C(N1CC=2C(=NN(C2CC1)C3CCOCC3)N4C=5C=C(C(=CC5CCC4)C=6C=NN(C6)C)C(F)F)C
Molecular Formula
C27H32F2N6O2
Molecular Weight
510.58
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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