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GN44028

Product Specifications

CAS Number

1421448-26-1

Target

HIF/HIF Prolyl-Hydroxylase, HIF

Related Pathways

Metabolism, Angiogenesis, Chromatin/Epigenetic

Purity

0.9952

Bioactivity

GN44028 (N- (2,3-Dihydro-1,4-benzodioxin-6-yl) -1,4-dihydroindeno[1,2-c]pyrazol-3-amine) is a hypoxia-inducible factor inhibitor of (HIF) -1 (IC50: 14 nM) . GN44028 inhibits hypoxia-induced HIF-1α transcriptional activity. However, It can not be suppressing HIF-1α mRNA expression, HIF-1α protein accumulation, or HIF-1α/HIF-1β heterodimerization.

Smiles

C1c2ccccc2-c2[nH]nc(Nc3ccc4OCCOc4c3)c12

Molecular Formula

C18H15N3O2

Molecular Weight

305.33

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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