GN44028
Product Specifications
CAS Number
1421448-26-1
Target
HIF/HIF Prolyl-Hydroxylase|||HIF
Related Pathways
Metabolism|||Angiogenesis|||Chromatin/Epigenetic
Purity
0.9952
Bioactivity
GN44028 (N- (2,3-Dihydro-1,4-benzodioxin-6-yl) -1,4-dihydroindeno[1,2-c]pyrazol-3-amine) is a hypoxia-inducible factor inhibitor of (HIF) -1 (IC50: 14 nM) . GN44028 inhibits hypoxia-induced HIF-1? transcriptional activity. However, It can not be suppressing HIF-1? mRNA expression, HIF-1? protein accumulation, or HIF-1?/HIF-1? heterodimerization.
Smiles
C1c2ccccc2-c2[nH]nc(Nc3ccc4OCCOc4c3)c12
Molecular Formula
C18H15N3O2
Molecular Weight
305.33
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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