Tazemetostat trihydrochloride
Product Specifications
CAS Number
1403255-00-4
Target
Histone Methyltransferase
Related Pathways
Chromatin/Epigenetic
Bioactivity
Tazemetostat trihydrochloride is a selective and orally available inhibitor of EZH2 (IC50: 4 nM for rat EZH2) . It inhibits the activity of human PRC2-containing wild-type EZH2 (Ki: 2.5 nM) . It inhibits EZH2 (IC50s: 11 and 16 nM in peptide assay and nucleosome assay) .
Smiles
O=C(C1=CC(C2=CC=C(CN3CCOCC3)C=C2)=CC(N(C4CCOCC4)CC)=C1C)NCC5=C(C)C=C(C)NC5=O.Cl.Cl.Cl
Molecular Formula
C34H47Cl3N4O4
Molecular Weight
682.12
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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