Edicotinib
Product Specifications
CAS Number
1142363-52-7
Target
C-Kit, CSF-1R, c-Fms, FLT
Related Pathways
Tyrosine Kinase/Adaptors, Angiogenesis
Purity
0.9972
Bioactivity
Edicotinib (JNJ-527) is a blood-brain-penetrating, orally active, selective CSF-1R inhibitor (IC50 value is 3.2 nM), with less inhibitory effects on KIT (IC50 value is 20 nM) and FLT3 (IC50 value is 190 nM) . Edicotinib (JNJ-527) can block microglial proliferation and attenuate neurodegeneration, and can be used to study Alzheimer's disease and rheumatoid arthritis.
Smiles
CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1ncc([nH]1)C#N)C1CC(C)(C)OC(C)(C)C1
Molecular Formula
C27H35N5O2
Molecular Weight
461.6
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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