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Edicotinib

Product Specifications

CAS Number

1142363-52-7

Target

C-Kit, CSF-1R, c-Fms, FLT

Related Pathways

Tyrosine Kinase/Adaptors, Angiogenesis

Purity

0.9972

Bioactivity

Edicotinib (JNJ-527) is a blood-brain-penetrating, orally active, selective CSF-1R inhibitor (IC50 value is 3.2 nM), with less inhibitory effects on KIT (IC50 value is 20 nM) and FLT3 (IC50 value is 190 nM) . Edicotinib (JNJ-527) can block microglial proliferation and attenuate neurodegeneration, and can be used to study Alzheimer's disease and rheumatoid arthritis.

Smiles

CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1ncc([nH]1)C#N)C1CC(C)(C)OC(C)(C)C1

Molecular Formula

C27H35N5O2

Molecular Weight

461.6

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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