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Dolastatin 15

Product Specifications

CAS Number

123884-00-4

Target

Apoptosis, ADC Cytotoxin, Microtubule Associated

Related Pathways

Cytoskeletal Signaling, Antibody-drug Conjugate/ADC Related, Apoptosis

Bioactivity

Dolastatin 15, a depsipeptide derived from Dolabella auricularia, is a potent antimitotic agent structurally related to the anti-tubulin agent Dolastatin 10. Dolastatin 15 can be used as an ADC cytotoxin and it induces cell cycle arrest and apoptosis in multiple myeloma cells.

Smiles

COC1=CC(=O)N([C@H]1Cc1ccccc1)C(=O)[C@@H](OC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](C(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C)C(C)C)C(C)C |t:2,@:48,@@:36|

Molecular Formula

C45H68N6O9

Molecular Weight

837.072

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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