Dolastatin 15
Product Specifications
CAS Number
123884-00-4
Target
Apoptosis, ADC Cytotoxin, Microtubule Associated
Related Pathways
Cytoskeletal Signaling, Antibody-drug Conjugate/ADC Related, Apoptosis
Bioactivity
Dolastatin 15, a depsipeptide derived from Dolabella auricularia, is a potent antimitotic agent structurally related to the anti-tubulin agent Dolastatin 10. Dolastatin 15 can be used as an ADC cytotoxin and it induces cell cycle arrest and apoptosis in multiple myeloma cells.
Smiles
COC1=CC(=O)N([C@H]1Cc1ccccc1)C(=O)[C@@H](OC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](C(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C)C(C)C)C(C)C |t:2,@:48,@@:36|
Molecular Formula
C45H68N6O9
Molecular Weight
837.072
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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