CUR61414 hydrochloride
Product Specifications
Target
Hedgehog/Smoothened
Related Pathways
GPCR/G Protein, Stem Cells
Purity
0.9522
Bioactivity
CUR61414 hydrochloride is a potent and cell permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM) . CUR61414 hydrochloride is a small-molecule aminoproline class compound. CUR61414 hydrochloride selectively binds to smoothened (Smo, Ki= 44 nM) . CUR61414 hydrochloride can induce cancer cells apoptosis without affecting neighboring non-tumor cells.
Smiles
Cl.COc1cccc(CN([C@H]2C[C@H](N(Cc3ccc4OCOc4c3)C2)C(=O)N2CCNCC2)C(=O)CC(C)(C)C)c1
Molecular Formula
C31H43ClN4O5
Molecular Weight
587.15
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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