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CUR61414 hydrochloride

Product Specifications

Target

Hedgehog/Smoothened

Related Pathways

GPCR/G Protein|||Stem Cells

Purity

0.9522

Bioactivity

CUR61414 hydrochloride is a potent and cell permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM) . CUR61414 hydrochloride is a small-molecule aminoproline class compound. CUR61414 hydrochloride selectively binds to smoothened (Smo, Ki= 44 nM) . CUR61414 hydrochloride can induce cancer cells apoptosis without affecting neighboring non-tumor cells.

Smiles

Cl.COc1cccc(CN([C@H]2C[C@H](N(Cc3ccc4OCOc4c3)C2)C(=O)N2CCNCC2)C(=O)CC(C)(C)C)c1

Molecular Formula

C31H43ClN4O5

Molecular Weight

587.15

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Curated Selection

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