CU-T12-9
Product Specifications
CAS Number
1821387-73-8
Target
TLR
Related Pathways
Immunology/Inflammation
Purity
0.9993
Bioactivity
CU-T12-9 is a potent TLR1/2 agonist (EC50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay) . It acts by activating the NFkB pathway, upregulating proinflammatory cytokines, and enhancing TLR1 and TLR2 dimerization.CU-T12-9 activates both the innate and the adaptive immune systems. CU-T12-9 selectively activates the TLR1/2 heterodimer, not TLR2/6. CU-T12-9 signals through NF-?B and invokes an elevation of the downstream effectors TNF-?, IL-10, and iNOS.
Smiles
CNc1ccc(cc1-n1cnc(c1)-c1ccc(cc1)C(F)(F)F)[N+]([O-])=O
Molecular Formula
C17H13F3N4O2
Molecular Weight
362.31
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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