Copanlisib dihydrochloride
Product Specifications
CAS Number
1402152-13-9
Target
PI3K, Apoptosis, mTOR
Related Pathways
Apoptosis, PI3K/Akt/mTOR signaling
Purity
0.9916
Bioactivity
Copanlisib dihydrochloride (BAY 80-6946 dihydrochloride) is an ATP-competitive pan-class I PI3K inhibitor, with IC50 values of 0.5 nM for PI3Kα, 0.7 nM for PI3Kδ, 3.7 nM for PI3Kβ, and 6.4 nM for PI3Kγ. It exhibits superior antitumor activity and demonstrates more than 2,000-fold selectivity against other lipid and protein kinases, except for mTOR.
Smiles
Cl.Cl.COc1c(OCCCN2CCOCC2)ccc2C3=NCCN3C(NC(=O)c3cnc(N)nc3)=Nc12
Molecular Formula
C23H30Cl2N8O4
Molecular Weight
553.44
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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