CMPD101
Product Specifications
CAS Number
865608-11-3
Target
PKC, GRK, ROCK
Related Pathways
Cell Cycle/Checkpoint, Chromatin/Epigenetic, Stem Cells, GPCR/G Protein, Cytoskeletal Signaling
Purity
0.9904
Bioactivity
CMPD101 is a membrane-permeable small-molecule inhibitor of GRK2/3 (IC50: 18 nM and 5.4 nM) . Which can be used for the study of heart failure. CMPD101 exhibits less selectively against GRK1, GRK5, ROCK-2 and PKCα with IC50s of 3.1 μM , 2.3 μM, 1.4 μM and 8.1 μM, respectively.
Smiles
Cn1c(CNc2cccc(c2)C(=O)NCc2ccccc2C(F)(F)F)nnc1-c1ccncc1
Molecular Formula
C24H21F3N6O
Molecular Weight
466.46
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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