CLP257
Product Specifications
CAS Number
1181081-71-9
Target
Potassium Channel
Related Pathways
Membrane transporter/Ion channel
Purity
0.995
Bioactivity
CLP257 is a selective K+-Cl− cotransporter KCC2 activator (EC50: 616 nM) and it is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4. CLP257 alleviates hypersensitivity in rats with neuropathic painc and it also modulates plasmalemmal KCC2 protein turnover post-translationally. CLP257 restores impaired Cl− transport in neurons with diminished KCC2 activity.
Smiles
Oc1cc(F)ccc1\C=C1/SC(=NC1=O)N1CCCCN1
Molecular Formula
C14H14FN3O2S
Molecular Weight
307.34
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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