Cenisertib
Product Specifications
CAS Number
871357-89-0
Target
Aurora Kinase, STAT, FLT, Akt, Bcr-Abl
Related Pathways
Chromatin/Epigenetic, Angiogenesis, JAK/STAT signaling, PI3K/Akt/mTOR signaling, Cell Cycle/Checkpoint, Tyrosine Kinase/Adaptors, Cytoskeletal Signaling, Stem Cells
Bioactivity
Cenisertib is A potent ATP-competitive multi-kinase inhibitor, showing inhibitory effects on the activity of Aurora-kinase-A/B, ABL1, AKT, STAT5, FLT3, as well as kinase inhibitors of FER and its homolog. Cenisertib inhibits the growth of tumor mast cells (MCS) by inhibiting the activity of several different molecular targets. Cenisertib also inhibits tumor growth in pancreatic, breast, colon, ovarian and lung cancer and leukemia in xenograft models.
Smiles
[H][C@@]12C[C@@]([H])(C=C1)[C@@H]([C@@H]2Nc1nc(Nc2ccc(N3CCN(C)CC3)c(C)c2)ncc1F)C(N)=O
Molecular Formula
C24H30FN7O
Molecular Weight
451.54
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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