CDKI-73
Product Specifications
CAS Number
1421693-22-2
Target
Apoptosis|||CDK
Related Pathways
Cell Cycle/Checkpoint|||Apoptosis
Purity
0.9811
Bioactivity
CDKI-73 is a potent CDK9 inhibitor (Ki: 4 nM) . It shows selective toxicity to CLL cells (LD50=80 nM) versus normal B cell and normal CD34+ cell (LD50>20 uM) .The inhibition of CDK9 induces apoptosis and potentiates the effect of cisplatin.
Smiles
CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)S(N)(=O)=O)ncc1F
Molecular Formula
C15H15FN6O2S2
Molecular Weight
394.45
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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